Glucozide MR 60 Dosage & Drug Information

Concise Prescribing Info

Contents

Gliclazide

Indications/Uses

Type 2 DM in adults when dietary measures, physical exercise & wt loss alone are not sufficient to control blood glucose.

Dosage/Direction for Use

Adult including elderly or w/ mild to moderate renal insufficiency Initially 30-120 mg once daily. Patients at risk of hypoglycemia Initially 30 mg daily. May be given in combination w/ biguanides, α-glucosidase inhibitors or insulin.

Administration

Should be taken with food.

Contraindications

Hypersensitivity to sulfonylureas, sulfonamides. Type 1 diabetes, diabetic precoma & coma, diabetic ketoacidosis. Severe renal or hepatic insufficiency. Concomitant use w/ miconazole. Lactation.

Special Precautions

Hypoglycemia. Monitor blood glucose levels & take exercise regularly. Severe hepatic or renal impairment. Patients w/ G6PD deficiency. Pregnancy (change to insulin before pregnancy).

Adverse Reactions

Hypoglycemia, abdominal pain, nausea, vomiting, dyspepsia, diarrhea, constipation, changes in haematology. Raised hepatic enzyme levels, hepatitis. Cholestatic jaundice. Transient visual disturbances at start of treatment, rash, pruritus, urticaria, angioedema, erythema, maculopapular rashes, bullous reactions eg, SJS, TEN & DRESS. Erythrocytopenia, agranulocytosis, haemolytic anaemia, pancytopenia, allergic vasculitis, hyponatreamia, elevated liver enzymes, liver function impairment (cholestasis, jaundice) & hepatitis.

View ADR Monitoring Form

Drug Interactions

Increased hypoglycemic effect w/ miconazole, phenylbutazone, alcohol, other antidiabetic agents, β-blockers, fluconazole, ACE inhibitors, H₂-receptor antagonists, MAOIs, sulfonamides, clarithromycin, NSAIDs. Blood glucose levels may be increased by danazol, chlorpromazine, glucocorticoids & ritodrine, salbutamol, terbutaline. St. John's wort (Hypericum perforatum) prep. Risk of dysglycaemia w/ fluoroquinolones. Potentiation of anticoagulants therapy.

MIMS Class

Antidiabetic Agents

ATC Classification

A10BB09 - gliclazide ; Belongs to the class of sulfonylureas. Used in the treatment of diabetes.

Thai FDA Category

Presentation/Packing

Form

Glucozide MR 60 tab 60 mg

Packing/Price

10 × 10's

Glucozide MR 60

gliclazide

Manufacturer:

Unison

Distributor:

Medline

Marketer:

Medline